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Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study
Vasc Spec Int 2019;35:22-27
Published online March 31, 2019;
© 2019 The Korean Society for Vascular Surgery.

Maria Tsachiridi1,2, George Galyfos1, Alexandros Andreou3, Argiri Sianou4, Fragiska Sigala1, George Zografos1, Konstantinos Filis1

1First Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, Greece, 2Department of Upper Gastrointestinal Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, 3Department of General Surgery, York Hospital, York Teaching Hospital NHS Trust, York, United Kingdom, 4Department of Microbiology, Areteion University Hospital, Athens, Greece
Correspondence to: George Galyfos, First Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, 6 Melinas Merkouri Street, Neon Iraklion, Attikis, 14122 Athens, Greece, Tel: 30-213-2086243, Fax: 30-210-2086455, E-mail:,
Received September 13, 2018; Revised December 9, 2018; Accepted January 5, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


The use of platelet-rich plasma (PRP) for the treatment of nonhealing ulcers is a relatively new technique. Although it seems to result in a satisfying level of healing and low complication rates, data regarding its effectiveness remain sparse. This study aims to evaluate the potential therapeutic effects of PRP on chronic nonhealing ulcers.

Materials and Methods

This was a prospectively designed study comparing outcomes between patients treated with PRP (Group A, n=15) and patients treated conventionally (Group B, n=12) for different types of nonhealing ulcers. In Group A, PRP was produced from the patients’ own peripheral blood samples and was applied on the ulcer once every week. In Group B, patients were treated conventionally, without applying PRP. The total treatment period was 5 weeks.


Both groups were similar regarding age, sex, comorbidities, and time of treatment. In Group A, patients showed a nonsignificant reduction of 4.5 mm2 in ulcer area (P=0.190) and a reduction of more than 1 mm in depth (P=0.0006), while Group B showed an increase of 108±80.5 mm2 in ulcer area after 5 weeks (P=0.016). The healing rate (HR) in Group A was stable and positive throughout the treatment period, while HR in Group B was initially negative but became positive after the 3rd week.


PRP application once a week promotes the healing of chronic ulcers. It improves the ulcer’s depth and HR, although its effect on ulcer area seems to be nonsignificant. However, larger comparative series are still needed to confirm these findings.

Keywords: Platelet-rich plasma, Ulcer, Regeneration